Functional Monitoring of Physiological Processes with Bioanalytical Microsystems
('Forschungsschwerpunktprogramm Baden-Wuerttemberg')
| Subproject Micro-Monitoring of Essential Physiological Parameters During Electrophysiological Investigations of Network Activity in Acute Brain Slices Dr. U. Egert and Prof. Dr. A. Aertsen |
The project aims to establish multiparametric functional assays of biological structures based on biosensors. New sensors are applied to a number of biological targets to investigate their physiological function and to create new techniques for high-throughput screening. In our subproject we will apply sensors developed by groups in the Institute of Microsystems Technology (see below) to determine activity-dependent local changes of important parameters in the extracellular environment. Key-targets are the dynamics of the concentrations of oxygen, glucose, glutamate, NO and pH in acute slice of the rat brain in changing states of neuronal activity.
This is a joint project of groups in the Zentrum fuer Angewandte Biowissenschaften (ZAB).
Participating labs:
| Prof. Dr. W. Haehnel | Plant Biochemistry, Institute of Biology 2 |
| Dr. U. Egert and Prof. Dr. A. Aertsen | Neurobiology & Biophysics, Institute of Biology 3 |
| Prof. Dr. A.Sippel | Institute of Biology 3 |
| Prof. Dr. Urban | Sensors & Bioanalytical Systems, Institute of Microsystems Technology |
| Dr. Nann | Sensors & Bioanalytical Systems, Institute of Microsystems Technology |
| Dr. Moser | Sensors & Bioanalytical Systems, Institute of Microsystems Technology |
| Dr. Schwab | Childrens Hospital of the Univ. of Freiburg |